Copy number variation made easy


Copy number variations (CNVs) in the human genome, such as amplifications and deletions, are attracting more and more attention both in basic research and in diagnostic environments, due to their potential phenotypic effects.

IMGM has recently started a new service to deliver accurate copy number data based on real-time PCR and proven TaqMan® chemistry.

Our CNV service is based upon a collection of over 1.6 million TaqMan® Copy Number Assays (Applied Biosystems), which are distributed over the entire genome and cover genes, known CNVs and extragenic regions.

Customers can simply submit a chromosomal location or gene of interest, and IMGM will select the appropriate Copy Number Assays.

Depending on throughput requirements, IMGM carries out your CNV study in 96-well or 384-well format. Well-known single copy reference genes (RNAse P, TERT) are included to standardize the measurements, resulting in reliable conclusions about amplifications or deletions.

By offering copy number analysis using TaqMan® assays, IMGM rounds off its array-CGH service for microarray-based comparative genomic hybridization: First, array-CGH can be applied to screen for chromosomal aberrations in the whole genome or in selected genomic regions, and then, Copy Number assays can be used as the ideal tool to validate the previous findings..

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